For one of Italy's most elegant cafe experiences, head to the extravagantly neoclassical Caffé Pedrocchi. Drinks are pricey, but the colorful 19th-century setting and whimsical references to ancient Rome and Egypt are worth the trip. In summer, sit out on the stone patio to watch the ebb and flow of Paduan life on the pedestrian piazza outside.
Simple, well-prepared food reigns at Osteria dei Fabbri, an old-fashioned osteria and a lively spot where intellectual types share tables with Zegna-suited bankers, and students stop by for a tipple. Some of the day's specials are displayed on the heavy oak bar—antipasti of grilled vegetables, rosemary potatoes, seafood salads—while hot dishes stream out of the kitchen (the house specialty: osso buco). Local wines available by the bottle or glass.
If Dei Fabbri is full, head two blocks over to the reliable Osteria L'Anfora for inexpensive wine and good food betwene Piazza Duomo and Piazza dell Erbeat.